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This paper addresses the deconvolution problem of estimating a square-integrable probability density from observations contaminated with additive measurement errors having a known density. The estimator begins with a density estimate of the contaminated observations and minimizes a reconstruction error penalized by an integrated squared m-th derivative. Theory for deconvolution has mainly focused on kernel- or wavelet-based techniques, but other methods including spline-based techniques and this smoothnesspenalized estimator have been found to outperform kernel methods in simulation studies. This paper fills in some of these gaps by establishing asymptotic guarantees for the smoothness-penalized approach. Consistency is established in mean integrated squared error, and rates of convergence are derived for Gaussian, Cauchy, and Laplace error densities, attaining some lower bounds already in the literature. The assumptions are weak for most results; the estimator can be used with a broader class of error densities than the deconvoluting kernel. Our application example estimates the density of the mean cytotoxicity of certain bacterial isolates under random sampling; this mean cytotoxicity can only be measured experimentally with additive error, leading to the deconvolution problem. We also describe a method for approximating the solution by a cubic spline, which reduces to a quadratic program. 

Many two-level nested simulation applications involve the conditional expectation of some response variable, where the expected response is the quantity of interest, and the expectation is with respect to the inner-level random variables, conditioned on the outer-level random variables. The latter typically represent random risk factors, and risk can be quantified by estimating the probability density function (pdf) or cumulative distribution function (cdf) of the conditional expectation. Much prior work has considered a naïve estimator that uses the empirical distribution of the sample averages across the inner-level replicates. This results in a biased estimator, because the distribution of the sample averages is over-dispersed relative to the distribution of the conditional expectation when the number of inner-level replicates is finite. Whereas most prior work has focused on allocating the numbers of outer- and inner-level replicates to balance the bias/variance tradeoff, we develop a bias-corrected pdf estimator. Our approach is based on the concept of density deconvolution, which is widely used to estimate densities with noisy observations but has not previously been considered for nested simulation problems. For a fixed computational budget, the bias-corrected deconvolution estimator allows more outer-level and fewer inner-level replicates to be used, which substantially improves the efficiency of the nested simulation.